Trivia: A running joke throughout the series is that no one knows where Springfield is. The writers are always coming up with ways to keep the audience guessing. Some examples of this are: in 'Sunday, Cruddy Sunday' when Marge phones the egg painting company and gives her address, she says, "742 Evergreen Terrace, Springfield Ohi...", then cuts out to say, "Oh hiya Maude!" to Maude Flanders, who suddenly appears in the kitchen. When Homer and Bart are off to the Edison Museum in 'The Wizard of Evergreen Terrace' they drive past a sign with exits to New Jersey, Michigan and Oregon, none of which are close to each other. When Larry Burns spots Mr. Burns on the train, he asks where the train is going. The conductor says, "Springfield." and Burns asks, "Springfield where?", but the conductor's reply is drowned out by the train's engine.
Trivia: In several episodes, one of Maggie's stuffed toys is a stiff-limbed rabbit. This rabbit starred in a comic strip Matt Groening used to write, about a rabbit and his journey through a troubled life. Titled "life in hell" it was renamed "life is swell" in recent years before concluding.
Trivia: Bart's anonymous prank calls to Moe the bartender were inspired by tapes of real-life prank calls made to New Jersey bartender Louis "Red" Deutsch (the tapes were widely circulated during the 1980s). Deutsch constantly received calls requesting fictitious bar patrons (Al Coholic, Stu Pitt, etc), and always responded in a hostile manner every time he realized he'd been duped.
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Trivia: Another gag that makes the location of Springfield more ambiguous. In one episode the superintendent of the Springfield school systems says "This school used to be the worst in the state of Missouri." Everyone gives him a shocked look, and then he adds "which was why it was moved brick by brick to its present location."
Trivia: Matt Growning did all his animation in black and white and another animator was in charge of coloring. When she chose yellow, Matt said it worked and liked it (consequently when she chose purple for trees they rejected it.) The idea behind the yellow after that is so when you're flipping through the channels and come across yellow animated characters, you'll know right away it's The Simpsons.
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Trivia: Hank Azaria, voice for many of the characters on the Simpsons, said in an interview with Conan O'Brien that most of his voices were just bad celebrity impressions. Moe Syzlak is Al Pacino, Louie the cop is Sylvester Stalone, and Comic Book Guy is someone he went to college with who had a personality much like comic book guys. With other characters who Azaria doesn't do are also celebrity impressions. For example, Mayor Quimby is JFK.
Trivia: In New Zealand when the show was being shown on the TV2 network, the Itchy & Scratchy cartoons over a period of time were continually edited to try and remove as much violent content from them as possible. However around 2000-2001 the network edited out every single Itchy & Scratchy cartoon making the cartoon almost non-existent in the show despite some of the cartoon's content not being as objectionable as the rest.
Trivia: Creator Matt Groening holds the world record for the most DVD commentaries by one person. In total he has done over 100 commentaries over the first five seasons on DVD. The only episodes from seasons 1-5 he has not commented on are "Call of the Simpsons", "The Telltale Head", "The Crepes of Wrath" (all season one), "Homer and Apu" and "Secrets of a Successful Marriage" (both season five).
Trivia: The Simpsons has a joke that has been run many times in different forms. They make a reference to the movie "Ben Hur", a movie about a Roman Gladiator. It has a famous chariot scene where one of his opponents has a chariot with spikes on the wheels. He uses it to cut up his opponents wheels and make them crash. This joke is frequently used in the show. It can be seen in the episode where they go to New York, where Bart makes a Soap Box racer, and many others.
Trivia: In the episode where the Simpsons go to Japan, Bart puts on a cartoon that causes everyone to have seizures because of flashing eyes. The same kind of thing happened to real children during an episode of Pokemon where a character's flashing eyes caused them to have real seizures.