Factual error: A woman is shown receiving electroshock treatment ("ECT") in a hospital scene which took place in 1928. Although chemicals were used to induce seizures in psychiatric treatments at the time, the use of electricity for the purpose was not discovered until 1937 and not used in the United States until 1940.
Continuity mistake: When the "substitute" boy gets off the train he is with an older women. The reporters ask the mom and boy to take a picture together. You can see from the camera angle that the older woman is in the background when the flashes go off taking the picture. Later in the movie, the psychiatrist holds up a newspaper article with the picture in it. In the newspaper picture, the older woman is not in the background.
Continuity mistake: When Angelina is sitting down at the table at the mental asylum, she is sitting across from a heavyset woman. Before she starts talking to the blond woman, the lady across from her takes a drink. Just as she is raising the glass, the scene cuts to another angle and the lady's glass is down on the table again.