Continuity mistake: In the scene at the gas station, Frank Martin grabs Valentina's arm to remind her of the bracelet and to not go too far. When he does, one shot shows him grabbing below the bracelet, the next shot shows him holding her above the bracelet, then the next shot below it again.
Other mistake: Near the end when the bad guy blows up in the train:The fireball created by the exploding bracelet would be much more suitable to several kilos of high explosive or a fuel explosion. I could NEVER been created by the amount of explosives stored in a bracelet (see as well Mythbusters, the James Bond episode with the exploding pen).
Factual error: When Frank's Audi plunges into the deep body of water underneath the bridge, he succeeds in using the air from the tires to fill some empty bags in the trunk with air in order to send the car back up to the surface. In reality, the air in the tires would not be enough to keep it afloat, no matter where it's stored. The air in the tires will expand by a factor of something like 33, but that's still not a large enough volume of air to refloat the car.
Other mistake: Franks Audi smashes through the steel barrier on the bridge. Whilst we can accept the bodywork is toughened up and is bulletproof, its a plastic front bumper, plastic grille, glass/plastic headlights, yet there isn't even a scratch on either of these items after the car is seen driving after its pulled from the river after smashing through said STEEL barrier. The barrier would be particularly strengthened to attempt to prevent such a maneuver that Frank performed.
Plot hole: In the large chase scene, Frank hits the shoulder at 140kph (~85mph) but the car doesn't shake, slide, or act in any way like it should. Later, when he's moving around 220kph (~135mph), he somehow manages to end up on two wheels. To top it all of when he ends up between the semis he appears to be moving just barely faster than them which would mean he had to slow down somewhere. When his wheels make contact with the one semi the car doesn't jump or skip as expected because it's not moving very fast compared to the semi. I know this scene is for effect, but they could at least attempt to make it somewhat based on real physics.
Plot hole: The main baddie is determined that no-one knows his name and is big on anonymity. Yet just after the foreign minister reveals in a phone call that he knows his name, he tries to call Frank and his name appears in the caller ID. So this big baddie who remains anonymous so no-one knows who he is gave Frank a phone with his name programmed in?