Factual error: As the two fast boats start heading up river towards the finale shootout, one boat has its navigation lights reversed. It has a red light on the starboard/right side, and a green light on the port/left side. It should be the other way around. (The lights on the other boat are correct.)
Factual error: Bodegita del Medio, where Sonny and Isabella go to get a decent mojito, is situated in the middle of the old town, and not by the sea as the view suggests.
Audio problem: In the scene inside the bar where Isabella is telling Crockett what happened to her mother (during the over-her-shoulder shot), her mouth doesn't match what we hear her saying.
Revealing mistake: In the balcony in Havana, when Sonny and Isabella are talking about her old house, the shoreline view is not nearly similar to the real "Malecon" in Vedado, Havana.
Continuity mistake: When Naomie Harris wakes up in the trailer after being abducted, she is rigged with a bomb around her neck. During the scene there is sunlight coming through the window of the trailer. The problem is that the whole section of the movie beginning, when she's abducted till she's in the hospital, takes place roughly between the hours of 2:00 and 4:00 A.M.
Continuity mistake: In the series of shots when Crockett and Tubbs have phoned headquarters there are several large red LED clocks in the background. The clocks jump ahead a few minutes with a few seconds on the phone but the funniest clock change is at the end when the minutes showing actually go backwards from 49 to 48.
Factual error: The Adam Air A500 aircraft that Sonny and Rico were using only has a useful load of 700 kg, which includes pilots and fuel. They couldn't have flown 1000 kg of cocaine out of Colombia.
Continuity mistake: When Jamie Foxx shoots a man, we see three shots of him. In the first and third shot, there's a large bullet wound in his chest, and a large part of his shirt is missing. But in the second shot, there's no wound, and his shirt is intact.
Other mistake: When Ricardo is translating the email while on the ship, he chooses the origin language as English and the destination language as Spanish. But when he presses translate, it translates from Spanish to English. (01:20:20)
