Continuity mistake: When Silent Bob renders the demon disabled by using the anti-odour spray, you see him take the spray out of his coat and spray with his thumb. However, it cuts to a front view, and he is clearly seen using his index finger. It then cuts to Bob's rear, and he is, again, spraying with his thumb.
Continuity mistake: When Bartleby and Loki go to the Mooby board room, Bartleby is listing the various Mooby products, and he forgets to mention the comic book. No one points out that he also never mentions the Mooby fast-food chain that we see the other characters at earlier in the film.
Continuity mistake: In the bar, when Azrael is doing his speech, everybody but Jay is listening to him; Jay is sleeping. It goes back to Azrael and he says something, the camera goes to Jay and he looks at Rufus, the camera then goes back to Azrael, and in the next shot Jay is sleeping again.
Continuity mistake: In the Mooby HQ scene, the CEO tells one of his executives to call security. The executive's hand is right on the phone when Loki throws a knife into it. The movie cuts to a close-up of the phone but the executive's hand is nowhere in sight. It then cuts back and you can see the executive with his hand back on the phone, right before he pulls it away when the phone shorts out.
Continuity mistake: In the beginning of the movie Loki is speaking to a nun about the church at the airport. When they sit down Loki puts his arm around her chair. When she starts to get up it is still there but then the split second she gets up both of his arms are in his lap.