Continuity mistake: For the first emergency landing, the co-pilot has his seatbelt on, then it is off a second later, then back on, then off again, then on again.
Factual error: They request an altitude of 40,000ft, however the service ceiling for an MD80 used in the film is 37,000ft. (00:09:00)
Continuity mistake: In the cockpit scene at the beginning you see them test their flight controls using a yoke (as used in Boeing aircraft) yet when you see a view looking at the flight instruments it's the layout of an Airbus A320, which uses a side stick operation.
Other mistake: Just when the tower clears 119 to take off, it shows the PFD and MFD screens. On PFD it shows air speed 250 knots and altitude 40000 feet which could only be happened when cruising in air. Also, on MFD it shows ground speed 250, and no flight path displayed. (00:09:00)