Continuity mistake: When Joan takes over cutting the leaves in the jungle, she drops the machete when she comes upon the skeleton. Neither she nor Jack bend over to pick it up, but Jack has it in the plane to kill the snake. (00:04:00)
Continuity mistake: When Joan and Jack arrive in the town, Danny De Vito is on the public phone to his cousin, Ira, and when he sees Jack and Joan, he says "You are the luckiest son of a bitch; she's coming right toward the phone booth," but he says this before Jack and Joan have even seen the phone booth, let alone walked towards it.
Continuity mistake: When Juan jumps the creek in his truck it lands on the other side, and then lands again in a following shot.
Factual error: Joan ends up taking the "wrong bus," which takes her "hell and gone from Cartagena." Its destination is labeled as "Castillo de San Felipe." However, in Colombia, Castillo de San Felipe is located inside the city of Cartagena itself.