Continuity mistake: When Michel finds the pink thong in the laundry and thinks it's his wife's, he climbs on her bed chewing on them playfully before she tells him it's his daughter's thong. Between shots when she puts the mechanical pencil on his lips and tells him, the thong is suddenly hanging out of his mouth much further. (00:05:00)
Continuity mistake: Jennifer Aniston is backstage at one of the beauty pageant contests she is a special guest for. They hand her the envelope with the winner. She is fixing her hair with the left hand, which turns into the right hand in the reverse shot.
Continuity mistake: Velma reluctantly agrees to Daphne's idea to check out of the mysterious locker. She says "We'll come up with something." Right part of the frame, and in the background there's an extra (black kid with a plaid white shirt) that is simultaneously also eating at the table in the reverse shot. (00:31:15)
Continuity mistake: In the final fight, Deadpool says to Cable "did you feel that too?" and there's no-one behind them at all. Cable moves forwards to kill a guy on the ground, and a fraction of a second later, as Deadpool says "only best buddies execute paedophiles together" an orderly has appeared in the background, who gets shot.
Factual error: Rhianna is watching a live feed of a man's office via webcam. We see a closeup of the screen. At the top it shows the filename being a ".jpeg." Jpegs are still image files, not movies, let alone live streams.
Continuity mistake: Sable is with a counselor discussing if his wife is cheating on him, and he has his hand resting against the side of his face. When the counselor is writing down his comment about riding dicks, it cuts to a close up of him and then his hand is almost on top of his head. (00:15:15)
Continuity mistake: At the wedding of her friend, Zoe drinks from her glass, looking 3/4 empty. Cut, and the glass is more than half full. (00:07:10)
Visible crew/equipment: When Zoe walks into Anderson's office and tells him she's meeting Maya at the apartment, just as Zoe says, "Uh oh," there's a visible blue T-mark taped to the floor. (00:49:05)
Continuity mistake: When Rick and Kirsten are at the game, just after they shout at one of the players, Kirsten drinks from her cup, but in the next shot, the cup is suddenly back in the armrest holster. (00:33:40)
Continuity mistake: When Phil heads to the Puppet Pleasure place early in the film, the positions of the shadows change around the vehicle parked out front in the close up, revealing the time laps between filming each shot. (00:06:30)