Factual error: When Sam and Dean are showing Jo pictures of H. H. Holmes' victims, the last picture was a victim that was not his. The final black and white is Jack the Ripper's very first victim.

Continuity: Near the end of the episode when Dean is being chased by the possessed truck, Sam tells him to take a left. After he's made the left, Sam tells him to go exactly 7/10ths of a mile and stop. Dean looks at his gage and it reads 70098.3. Dean looks up, then back at it: it changes to 70098.5, but the next time he looks down it says 70100.6 and when he stops it says 70101.0, meaning he's gone 2 miles too far. (Probably meaning it took two shots to get the scene right but they messed up on the gage.)

Continuity: In the scene where Dean is with Bobby at the burned down Roadhouse and Dean gets Andy's vision about where Sam is, the first time Dean scrunches his face in pain he puts his left hand to his head. The shot changes to a back view and you can tell his left hand is still at his head. But when the shot switches again Dean is bringing his right hand down from his head.