Continuity mistake: When Dean reads about the Roosevelt Asylum in his dad's journal, there is a picture of a Wendigo on the opposite page of the newspaper clipping but in a different scene, Dean checks the article again for information on the South Wing in the Asylum but this time on the opposite page of the newspaper clipping, there is no picture.
Continuity mistake: During the scene where Sam is tied up and eventually fights the fake-Dean in Becka's house, there is a shot that shows both his feet and hands tied. During the fight, both his hands and feet are shown free, but he only cut free his hands, and began fighting immediately after that.
Continuity mistake: The baby gets into the fridge, which then closes - we see a closeup shot of the babyproofing clip shutting itself. Then when the mother sees the spilled milk and realises what's happened, there are a few shots of the fridge - in shots from the front the clip's open, and in shots from the side it's closed. When she goes to open the fridge it's open again - she even fiddles with it to give the appearance of undoing it before opening the fridge door.
Continuity mistake: In the scene where Dean is with Bobby at the burned down Roadhouse and Dean gets Andy's vision about where Sam is, the first time Dean scrunches his face in pain he puts his left hand to his head. The shot changes to a back view and you can tell his left hand is still at his head. But when the shot switches again Dean is bringing his right hand down from his head.
Continuity mistake: When Dean kisses the Crossroads Demon, his head is tilted left, but when it cuts to the next shot his head is tilted to the right. It switches back and forth in the next two shots too quickly for Dean or the demon to move their heads.
Continuity mistake: Before the Roadhouse fire, Ash and Dean are talking on the phone. Ash looks at his watch, on his left hand, it says 8:10, and has a black dial/face. As Dean and Bobby go through the rubble, Dean identifies Ash by his watch. Still on his left hand, it is now upside down, evident by the crown of the watch (used to move the hands of the watch) which previously facing his hand, is now facing his elbow. Also, the dial/face of the watch is now silver instead of black. This is a different watch, and was inadvertently put on the burnt arm upside down.
Continuity mistake: When the Deputy handcuffs Dean to the car door handle, he uses a small radio/cell antenna from the car to pick his handcuff lock (attached to his wrist), just as the bad guys walk toward the car. When the bad guys get to the car Dean is gone and so are the handcuffs (including the cuff that was attached to the door handle). Dean did not have time to pick both handcuff locks.
Continuity mistake: Near the end of the episode when Dean is being chased by the possessed truck, Sam tells him to take a left. After he's made the left, Sam tells him to go exactly 7/10ths of a mile and stop. Dean looks at his gage and it reads 70098.3. Dean looks up, then back at it: it changes to 70098.5, but the next time he looks down it says 70100.6 and when he stops it says 70101.0, meaning he's gone 2 miles too far. (Probably meaning it took two shots to get the scene right but they messed up on the gage.)
Continuity mistake: When Sam and Dean enter the Shoemaker home, a woman leaning against a wall holding a coffee cup starts to follow them down the hall. When the shot changes, the woman is back against the wall, talking to someone who wasn't there in the previous shot.
Continuity mistake: In the scene where Jill is looking at her 'Bloody Mary' reflection, the lines of blood coming from her eyes go down and straight over her mouth (because she hasn't smeared them like the real Jill has). But as she begins to talk, the lines switch from being over her mouth to off to either side of her mouth and back multiple times.
Continuity mistake: In the scene where the passengers board the plane at the beginning, the aircraft is a Boeing 737, noticeable by the crew jumpseats located by the entrance door. But the first scene you see where the aircraft is in flight, the aircraft changes to a Widebody Airbus, possibly an A310, noticeable by the different style of winglets that Airbus uses compared to that of Boeing.
Continuity mistake: Season 6 Episode 15 'The French Mistake': When Sam and Dean are first talking to Misha, the collar of his shirt is tucked into his jacket, as normal. However it suddenly is sticking out over the top of his coat, then changes to being tucked in again, with no time for him to have changed it himself.