The show was filmed in an actual prison (now unused) in Joliet. The death row cell used for Lincoln Burrows is the actual death row cell that held serial killer John Wayne Gacy. See more...
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Factual error: When they have escaped, and the dogs are barking at them as they hide in the bushes, this couldn't have happened the way the show presented it. The spot that they escaped is on the main road (Collins Street, also, it was to the left of the screen from where Joliet Jake came out in 'The Blue's Brothers) The dogs are barking at them as they hide in the bushes, and that location is on the -other- side of the Prison. There is NO way that they would be able to circle around the prison and get from one side to the other considering in the front, there are fences surrounding the main building, obstructing you from going that way. The back side of the Prison (There it a road next to a junk yard located right next to the Prison, the same road that is used to get to the 'Gate' the cons are looking at when the dogs are barking. That road would have been full of cops, since all the cops are in the parking lot. It would have been more believable if they would have went across the street to where the women's facility was, and were shown on camera looking across to the parking lot out front.
Revealing: After Pope enters Scofield's cell to see the escape hole, we see him standing outside the cell looking out at everyone throwing toilet tissue etc. If you watch closely right after we see a guy pulling his pillows toward him to tear up, it cuts to another inmate who is throwing stuff out as well. Only thing is, we see the cell door slides to the side slightly which would indicate that the cell doors where not locked. In the event of an escape, lockdown would happen immediately, with all cell doors locked with the prisoners inside their cells.
Revealing: In the episode where Scofield, Sucre and T-Bag are driving in Panama, the trees in the background have no leaves - like Autumn/Winter in the US. And even though there of course are trees in Panama which shed their leaves, there is no time of year when all trees are leafless - like in the temperate zones. That shot was definitely not filmed in Panama.
Factual error: Season 2, Episode 10: Linc and LJ are saved by Linc's father's people near Wilcox, Arizona. They are taken to Linc's father in Trinidad, Colorado. It is shown as taking only a short while, and the other events have not come very far during the transportation. Sarah is still getting ready to meet Michael. However, Wilcox - Trinidad is a 10 hour drive.
Continuity: Series 2 - Episode 10. When Sara is to meet Michael at 1681 Butterfield Road Sara looks in the mailbox. She closes the lid, yet the mailbox is seen standing with the lid a bit open. In the next couple of shots the mailbox is completely open, and when they jump in the car and leave, the lid is now closed.
Continuity: Episode 14 - John Doe. Bellick is in the prison, and is being threatened by 'Banks.' As Banks and his crew walk away, in two different shots, you can see an elderly gentlemen (looking like Charles Westmoreland) walk across the screen, left to right. He does this twice, without there being time for him to run around.
Continuity: When Steadman is watching the agent put the bags that contain the remains of Veronica Donovan into the trunk of the silver car, the license plate changes between shots. The first time we see the car, the plate reads "1029Q", the second time (close-up shot as the agent closes the trunk) it reads "9417X".