The show was filmed in an actual prison (now unused) in Joliet. The death row cell used for Lincoln Burrows is the actual death row cell that held serial killer John Wayne Gacy. See more...
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Updates: 
Series 2
Continuity: This happens in the scene where Lisa is scolding LJ for getting arrested. When LJ says "I don't have a father", he is leaning on the table with his arms crossed. When the shot changes, his arms are uncrossed and in a completely different position.
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