Anthony Zuiker chose to set the series in Las Vegas because that city's crime lab is the second most active in the United States, behind the FBI lab in Quantico, Virginia.
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Catherine Dent's character, Kay Marquette, plays the Holmes character Irene Adler with an English accent. Adler was an American, as mentioned by Watson in "A Scandal in Bohemia". See more...
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Across whole show
Anthony Zuiker chose to set the series in Las Vegas because that city's crime lab is the second most active in the United States, behind the FBI lab in Quantico, Virginia.
Under the glass top of Grissom's desk are pictures of Jerry Bruckheimer, the shows executive producer.
Season 9, episode 20, titled "A Space Oddity"- In the scene where Simms translates the alien language that Hodges spoke to her earlier in the show with the Vellikon translator on the Astro Quest website, the alien alphabet that is shown on the computer screen is the same alphabet used in the Star Wars Universe, not Star Trek, which the show is modeled after.
Sounds of Silence (series 1)
For those who don't (or can't) read American Sign Language, at the end of the episode, Grissom says to Dr. Gilbet is that his mother lost her hearing when she was eight years old. He once asked her what is it like to be deaf, and she told Grissom (who loved to swim) that it was like being underwater. She also taught him that being deaf does not make one inferior to others. Dr. Gilbert then replies that she teaches her students the same lesson.
Ellie (series 2)
Anthony Zuiker, the show's creator, makes a cameo appearance at the very beginning of this episode; as the clerk who turns away the couple with the fake casino chips.
Last Laugh (series 3)
Series creator Anthony Zuiker has a cameo appearance as a heckler in the episode's final scene.
Abra Cadaver (series 3)
This episode featured a guest appearance by Tom Noonan. Noonan and series star William Petersen played villain and hero, respectively, in the film "Manhunter."
Suckers (series 4)
The runner-up nickname for the dummy was Pam Anderson.
Weeping Willows (series 5)
The man who flirts with Catherine at the bar is played by Marg Helgenberger's husband, Alan Rosenberg. According to Helgenberger on the DVD commentary, Rosenberg had difficulty treating her the way his character does, even though it was a fictional encounter.
Up In Smoke (series 6)
When Katherine and Sara find the girl's body in the chimney, Sara references a conversation they had earlier. But instead she calls the Poe story "The Tale Tell Heart."
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