Continuity mistake: Stewie tries to get his mind control device back from the kitchen. The cupboard door is open when he falls. In the very next shot, Lois turns the light on in the kitchen, and we see the door has closed without anyone touching it. It is open again after that.
Audio problem: When Peter goes down to the basement, the Pawtucket Patriot guy appears and Peter thinks he's coming on to him. He says, "Listen, I don't swing that way, pal. I got a date with my female wife, I just came down to get some beers." However, his lips very obviously do not sync up with those words.
Continuity mistake: After Lois says, "When Meg and Chris turned one I missed everything," it flashes back to Lois writing 'happy birthday Meg' on the cake, and there's wallpaper border at the top of the walls, but when Peter asks her what she's doing in the kitchen the wallpaper border is gone. The paper cups that Lois filled with punch also vanish, and the rolling pin, board, etc. suddenly appear.