Continuity mistake: This is a mistake for the introduction from seasons 2-20 (1991-2009). When Homer screams, he turns round. You see this in a wide shot. There are no boxes to the right of the door in the garage. However, two just appear out of thin air when he runs through the garage. (00:01:50)
Trivia: Maggie scans as $847.63 in the supermarket at the beginning (not NRA4EVER, as Troy Maclure asserts in 3F31 "The Simpsons 138th Episode Spectacular), the price it costs to feed and care for the average American baby every month.
Continuity mistake: When Bart leaves the school, you can see that his skateboard is green and perfectly flat. But when he is skating through the crowd and past the people at the bus stop, the skateboard has an orange stripe down the middle and is raised at the rear.
Continuity mistake: When Maggie goes through the checkout at the beginning, Marge's trolley is grey and has a red handle. But in the next shot, when Maggie pops out of the bag, the trolley handle is turquoise. (00:00:30)
Continuity mistake: In the introduction, initially Maggie's seat is light purple. However, in the wider shot of her and Marge, the seat changes to a burgundy colour. (00:00:50)
Continuity mistake: In the new opening credits (from Feb 09) when the camera is zooming into the bullies cutting the head off the statue Ralph Wiggum is nowhere to be seen, but when the head falls off, it lands on Ralph. (00:00:10)
Continuity mistake: In the old main title sequence, when Homer gets out of his car, the door inside the garage is red, but when he is screaming and running towards it, it's now brown. (00:01:40)
Trivia: In the opening sequence post Feb 2009, Marge can be seen placing items on the checkout. These include the detergent Mr Sparkle from Season 8 Episode 22, In Marge We Trust, and some Tomacco juice from Season 11 Episode 5, E-I-E-I - (annoyed Grunt). (00:00:25)
Continuity mistake: In the title sequence Mr. Largo has a baton in his hand when conducting. This disappears as he stops conducting to throw Lisa out. (00:00:50)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer