Continuity mistake: When Otto hits Hans Moleman's car, it has a number plate on it, which disappears when he crashes.
Continuity mistake: Just before Homer is sucked into Hell, he is wearing pyjamas. When he's in Hell, he's wearing his usual day clothes.
Continuity mistake: While Lisa is standing in front of the table with her friends in the cafeteria, we see that the trays appear during the first shot, then after the camera zooms in on Lisa's table, the trays disappear. Then during the third shot, Lisa calls Alex over to her table. Look at the table again: the trays have reappeared.
Plot hole: When Bart locks Principal Skinner and Mrs Krabappel in Skinner's office, and tells them that they can't come out until they've reached an agreement, why didn't Skinner and Krabappel just climb out Skinner's office window instead of spending hours pounding on the door yelling to be let out?
Other mistake: When Ned Flanders is calling Marge and Reverend Lovejoy from the Leftorium, he says that the three hooligans are in the shop on their motorbikes. But a few minutes before when Ned goes outside the shop to tell the boys to clear off, their bikes are nowhere in sight.