Frasier: Roger, at Cornell University they have an incredible piece of scientific equipment known as the Tunneling Electron Microscope. Now, this microscope is so powerful that by firing electrons you can actually see images of the atom, the infinitesimally minute building blocks of our universe. Roger, if I were using that microscope right now, I still wouldn't be able to locate my interest in your problem.
David Hyde Pierce made a guest appearance on "The Simpsons" as the brother of Kelsey Grammer's character Sideshow Bob. See more...
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Updates: 
Series 11
Continuity: Frasier is sitting on the couch watching Wheel of Fortune and eating, with a plate on his stomach. As he talks to Niles he places the plate on the coffee table. Niles says "Are those profiteroles?" and Frasier gobbles them up. Then we see Frasier put the plate on the table again.
Continuity: After calling Martin the "Sultan of Brunei," Frasier grabs his wine glass with one hand on the top and walks out of the kitchen. In the next shot when he is coming out he is holding it by the neck and there was no time for him to change his grip.
Audio problem: When Frasier and Martin go to see the woman play the piano it's very badly dubbed. Quite often her hands are at totally the wrong end for the sound the instrument is producing.
Continuity: Right at the start when Frasier is talking to Niles in the furniture shop, at one point he says "Don't you hear that," and holds his hand in a fist. The shot cuts instantly to Niles and you can see his hand is now about a foot higher and his palm is suddenly open.
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