Corrected entry: The time Dead Space takes place is 2414, but the USG. Ishumura was built in 2446.
Bug: Only on PS3: At times, when traversing the zero-G section to get to the air purification system in Chapter 6, some of the lurkers there will disappear (try bypassing them rather than killing them to reproduce). If this happens, then the power nodes whose destruction opens the doors to the air purification jets will not be present (as well as the flammable tanks which are supposed to be there), rendering it impossible to open the doors and kill the poison sac beyond them. This is a game breaker.
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Correction: The Ishumara was launched after being built in 2446, Isaac Clarke was born in 2465 and the Ishumura was sent to Aegis VII in 2508 and then the events of Dead Space takes place a few of months later. There was some confusion, but the dates have been confirmed and nothing significant happened in 2414.