Bug: If you switch from playing Michael to Trevor, there is one occasion in the game where Trevor has a man tied to a support beam underneath a pier. If Trevor chooses to use his Jerry can and spills gasoline all around the man and sets it on fire, the tied up man catches fire, however, a glitch occurs in the process. The man catches fire, screams, then somehow pops straight out of the ropes keeping him tied up and starts running around. The rope has also not changed shaped and still remains stretched out at the front. The man then suddenly pops back into the ropes and stays tied up before he dies.
Plot hole: Cleaning out the Bureau: At the garment factory, Michael arrives, agent Dave Norton arrives and later in the scene, agent Steve Haines arrives at the building, walks up the stairwell and says hello to the others. Apparently, the plot has completely forgotten that Steve had shot himself in the leg in the mission "Monkey Business" a few missions prior, to make himself appear as a double agent - he is walking around completely fine in this mission as if nothing happened.
Bug: Go to Franklin's first house in the neighbourhood and have Franklin place a sticky bomb anywhere on the walls or ceiling in the hallway and place the bomb by throwing it from the front door. After the explosive is thrown and lands on the wall, a slight glitch in the animation occurs. The entire explosive won't actually be visible on the wall. No matter where the shot is angled at, the beeping red light on top of the explosive will always be visible, however the rest of the explosive won't actually be in sight. If the angle of the shot is rotated, the explosive will appear from different views, but still a glitch nonetheless.
Other mistake: Franklin and Lamar: Franklin and Lamar begin by entering two cars: a red car and a white car. If Franklin gets in the red car, then Lamar will get in the white car. As Lamar enters the white car, he is never shown pulling a handle. He is just miming the actions of pulling a handle and the car door just opens.
Continuity mistake: The Big Score: Once Franklin has drilled down the wall between the underground construction site and the bank's vaults, Franklin will have to blow down the cages where the gold is contained. After blowing down the cages, there will be a hole in the door for the others to take the gold out of the vaults and the NOOSE team will appear to take everyone out. If Franklin is killed by the NOOSE team, he will have to drill down the wall and blow the cages all over again. When Franklin goes to blow down the cages, the cage doors are now in the position they were in when they were blown off during the previous attempt, even though Franklin hasn't actually gotten to this part yet.
Audio problem: Parenting 101: Once Michael reaches the car Jimmy is being kidnapped in, Michael receives a call from Jimmy's phone and the kidnapper is heard asking Jimmy who the man chasing them is. Jimmy is then heard yelling at the kidnappers, telling them it is his dad, but Jimmy is banging on the rear windscreen yelling at his dad and isn't even talking with the kidnappers.
Bug: Reuniting the Family: After Michael and Jimmy have picked up Tracey from the tattoo parlour, Michael drives them in his car to Dr. Friedlander's office. On the way, if Michael chooses to do a stunt jump off the Jetty Hotel, the car is mostly invisible, and the only part actually visible is the car's outline. As the jump progresses, the car becomes more visible, until the car is fully shown.
Continuity mistake: Paparazzo - The Sex Shoot: Franklin and Beverly run back to Beverly's car with the sex tape footage, they then enter the car and drive off. When Franklin enters the car, he is shown entering the door to the left back seat, behind the driver's seat. We don't actually see him enter, but he is not shown entering the right side door of the back seat and he was definitely on the back row, as shown when he then tries to film Poppy driving, so he definitely entered through the left back seat. After they have filmed the footage of Poppy chasing them, Beverly stops the car to allow Franklin to exit. Franklin is now sitting in the right hand side back seat.
Continuity mistake: Scouting the Port: After arriving at the docking area in the truck, the security guards begin attacking Floyd and Trevor runs off with a briefcase. When the guards begin attacking Floyd, Floyd and the guards are shown in front of the truck and also in front of the gate. The scene then cuts back to the game where Trevor has to escape and suddenly, Floyd and the guards are shown behind the gate.
Continuity mistake: Scouting the Port: When Trevor and Floyd arrive at the docking area, they are stopped by the security guards before they can enter. There is a gate shown right in front of where they stop and the gate is open. The gate is never touched once in the cut scene but when it cuts back to the game, the gate is suddenly closed.
Bug: There is a garage in the apartment building of Wade's cousin, Floyd where Trevor can save the vehicles he parks there. There is one space where a vehicle can be parked in the garage and that space is located next to the staircase. The car that is parked there may not be big enough to park and will end up getting wedged between the stairs and three bins shown next to the wall if the space between the stairs and wall isn't big enough. If Trevor walks into the car, the three bins next to the car will then start sliding up the car.
Plot hole: Trevor Phillips Industries: After arriving at the Meth Lab, Trevor tricks Mr. Cheng and his translator into entering an ice freezer. The translator then asks for Trevor to let him out and starts banging on the door. Trevor never locked the door and there is nothing restraining the door as Trevor had just opened it a second ago, so the translator could have simply just pushed the door open if he wanted to exit the ice freezer.
Plot hole: Marriage Counselling: Michael destroys Martin Madrazo's house, believing it to be owned by the tennis coach. Within the 0.6 mile drive back to Michael's house, Madrazo's henchmen are suddenly firing on Michael and Franklin because Michael destroyed the house. Even if the woman at Madrazo's house told Madrazo about the incident, there should still be no way for Madrazo to know what Franklin or Michael looked like, what they were driving, or where they were going.
Continuity mistake: Repossession: Franklin and Lamar must chase down a man who stole their bike in their car. One of the ways they can stop this man is by running him over with the car. Once Franklin goes back for the bike, the body of the man is nowhere in sight. This only applies as long as the thief had been run over with the car.
Character mistake: When Franklin is at the strip club and is being given a lap dance in the private room, Franklin can flirt with the stripper. The fourth thing Franklin says to flirt with her is that he loves her tattoos, even if the stripper giving him the lap dance doesn't have any tattoos.
Continuity mistake: The Bureau Raid: After celebrating at Lester's house, Michael leaves whilst Franklin and Lester are celebrating together. Franklin then receives a call from Dave. Franklin is never shown exiting the house, but if you choose to switch to Franklin after making the call, he is suddenly shown walking around Los Santos, even though he was just shown celebrating with Lester.
Revealing mistake: Just before you enter the Jetty hotel, there is a short driveway you drive up before reaching the parking garage. There are yellow lines along the side of the driveway, however, they are never shown from each angle of the camera. If the shot is rotated around, there is an angle where the yellow lines will just vanish, and there is an angle where the yellow lines will appear.
Other mistake: The Merryweather Heist: At the end of the mission, Franklin, Michael and Lester exit the airstrip and Trevor is still there. Trevor, in rage, bashes his head repeatedly on a wooden crate lid. Blood visibly appears on the crate lid. However, there is not a single drop of blood visible on Trevor's face.
Continuity mistake: Paparazzo - The Sex Shoot: Franklin walks up to Beverly just before the opening cut scene begins. As Franklin is walking up, Beverly is shown holding his camera pointing forwards, slightly to the right. The scene then cuts to the opening cut scene and Beverly is suddenly holding the camera much more to the right.
Continuity mistake: Paparazzo: After Franklin and Beverly have stopped the rival photographer, Franklin then has to drive Beverly to his next stakeout. Franklin stops Beverly's bike in the car park for Beverly to get off. At the moment where the bike stops, Beverly is shown holding his camera with one hand whilst he holds on to Franklin. The scene then cuts to the cut scene where Beverly is suddenly shown holding the camera with both hands.