Audio problem: After the part where Johnny Depp finds his bookstore friend dead, he gets back in the cab. After driving for a while, he tells the cab driver to pull over to the phone booth. The cab driver says something like "OK, yes sir" but you can see the cab driver's lips in the rear view mirror, and they never move.

Factual error: Throughout the film, the supposed rare book experts smoke over and around the books and always handle the books with their bare hands, instead of cotton gloves. Either one of these could destroy the extemely rare books.