Continuity mistake: When Rango was at the mayor's office, the mayor grabs out a jug of water, and he opens the lid. But in the next shot, the lid is sealed again.
Continuity mistake: In the scene where the passing truck blows Rango off the armadillo, he gets caught by a mud flap. (This is in the exact area where it was so hot, that the water from his glass dries up in seconds and his drink umbrella goes up in flames). But while he is stuck on the flap, he gets hit with a big juicy blast of watery mud off the road.
Continuity mistake: Around the beginning of the movie, when Rango is called by the armadillo, he's shocked and drops the glass in his hand, followed by the breaking sound, but as the scene continues, the shattered glass is nowhere on the road.
Continuity mistake: During the vending machine scene, besides the fact that he's hiding in slot D8, many of the slots are mislabeled. However, he is 2 positions in, so it would require $.50 to get him out, not $.25. And the slot on his right goes from having candy in the back, to having a different candy up front, then to being empty.
Continuity mistake: The one arm on the doll is on the right side in the opening scene. After Rango falls out of the car, it has switched to the left. At the end of the movie, it is back on the right.
Factual error: The 'Mayor' says he's a Turtle, but he's actually a Tortoise. Turtles have paddle type limbs for swimming, not reptile like paws as depicted in the movie.