The position of Ambrose's body changes from when Ethan has knocked him out, to when Ethan takes the antidote from his jacket pocket (you can glimpse Ambrose's body in the background), and again, back to his original position when he pulls a gun on Ethan. Plus, the rock that his head was propped up on disappears. [Ambrose's body can change position because he's still alive and fairly conscious; later on he is still strong enough to pick up his pistol to attack Ethan from behind. As for the disappearing rock. well, that IS a mistake.]

At the end, when Tom Cruise throws the knife at Dougray Scott's feet, there is a quick succession of shots consisting of the two in a fistfight. In one of the quick shots, there is a distinct black shape at the bottom right side of the screen that belongs to neither Cruise or Scott. The shoulder of a crewman who got a little too close, perhaps? [I checked that scene a couple of times, even pausing it from time to time, but I can't see anything.]

The man who Hunt's team tricks into thinking he has Chimera is allegedly somewhat knowledgeable about viruses and yet alludes to penicillin as a previous wonder drug in the fight against them. Penicillin has NO effect on viruses, it works on bacteria. Similarly, Nyah is likened to being another 'Typhoid Mary'.. another misplaced bacterial reference. [The "Typoid Mary" reference is simply a reference to someone spreading a dangerous disease, and how they are remembered. Whether the disease is spread by a virus, bacteria, microbe, or other method makes no difference in terms of the large scale effects, and how the person will be viewed.]

The main villain in this film (Ambrose) is supposed to be an active IMF Agent. A CIA operative can't apply for an auto loan without his superiors finding out, but a high-level agent of an entirely black-ops agency with the resources of the IMF can go completely evil, hire a subservient lacky and a whole army of henchmen, own a whole fleet of autos and motorcycles and an arsenal of explosives and weaponry, and the IMF has NO idea whatsoever until he crashes the plane (a task that would take extensive planning)? The movie seems to completely ignore the fact that this guy is a current employee of the US government and not some international criminal. [He's apparently not the one making the purchases. He's just the one making the decisions and giving the orders. As a "high-level agent" he knows how the IMF finds stuff out and takes the appropriate steps to avoid this. Pretty cut and dried.]

The scientist who injected himself with the Chimera virus decided to cut things way too close. He says in the video that he must travel from Sydney to Atlanta in less than 20 hours. He is then shown flying on commercial airlines. A flight from Sydney to LA takes 15 hours, and a flight from LA to Atlanta takes 5 hours. He didn't leave himself any time at all for error or delays. [Character mistakes aren't movie mistakes.]

In the first night that Nyah is in Ambrose's house she meets with Ethan outside the house and they talk for about 1 1/2 min.  Then we find out "Ethan" was really Ambrose with one of those "high-tech" masks.  My question...After being in bed with both, how come Nyah didn't recognise Ambrose is about 5 inches taller than Ethan? [Character mistakes aren't movie mistakes.]

Throughout the film, Ambrose has relatively short hair (on the back of his neck). But at the horse-racing scene at the beginning of the film, you can see that his hair at the back of his neck is exceptionally longer than at any other point in the movie. [Ever heard of a haircut? There is no continuity problem.]

Before Tom Cruise is going to break into the lab it is said that the lab with the Chimera virus is on floor 47 but later when Tom Cruise sets off the first explosion in the lab the computer flashes Security Breach on level 42. [What is said is that Chimera is on the "forty-second" floor - apparently it sounded like "47."]

At the end of the movie when Tom kicks the gun from the sand, firstly, it would be impossible to kick the gun so that it flies directly vertical from where it lies, secondly if you look closely, you can see the 'fishing line' that is attached to the gun to make it fly up vertically. [If you can see the fishing line, then yes, that is a mistake. However, it would still be possible. He hooks his toe under the gun by pushing his foot into the sand. He could still "kick" the gun up towards his hand.]

When Tom Cruise is on the bike near the end, he shoots the gas tank of a car following him and it blows up. However, his bike takes a bullet in the gas tank and it doesn't explode. [The bullet doesn't hit the tank, it hits the fuel line.]

After Ambrose realises that he has just shot Hugh Stamp, there is a car chase, where Hunt shoots at a bronze coloured car. If you look closely you can see that it is in fact Hugh Stamp driving, though he died minutes before. [It is a blond guy but not Hugh Stamp.]

When the 2 Triumph bikes square off on the beach, just before they race towards each other Tom & Dougray rev their bikes. It's a really fast cut between the two throttles but Dougray twists his left wrist, which does nothing on a bike. [It appears to actually be Tom twisting the throttle with his right hand on his Triumph Speed Triple - however the scene has been flipped - as the brake fluid resevoir - which is also on the right hand side bike - is visible. So it just looks like a left-handed throttle twist but is really a right-handed one that has been reversed. ]

At one point we saw the memory card for the camera up close and it read '2 MB' on it. Later we see the contents of this memory card which is a complex animated video. 2 MB would be no where near enough to store the showed video sequence. [Actually it says 32 MB on the card.]