Continuity: When Agent Strahm has finally realised where the final game is being played, he holds up the piece of paper of Jigsaw and Art outside the Gideon building. There is a hand at the top of the picture, which is a newspaper clipping, but he is holding a picture, not a newspaper. This is a reused shot of when he shows Agent Perez the picture earlier in the movie.
Continuity: *SPOILER* When Agent Strahm breaks into the Jigsaw's room in the end, he literally comes in less than a minute after "Saw III"'s conclusion. Yet, if you look, Amanda's dead body is in a completely different position than the end of "Saw III", which makes no sense, as there was no time or reason for it to be moved. At the end of III, her body was facing towards Jigsaw, and there was only a small amount of blood around her. Here, her body is facing in a different direction, and there is a ridiculously larger amount of blood.