Director Sam Raimi's daughter makes a cameo appearance as the little girl who sells her camera to J. Jonah Jameson near the end. See more...
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Continuity: In the scene where Marco falls into the sand molecular chamber, if you watch closely when Marco looks up in one shot you can see he is wearing a chain around his neck, yet in the following shot when the lights come on the chain has gone, and then the shot changes to the scientists, then back to Marco where the chain has reappeared on his neck.
Continuity: During the final fight scene, Spiderman is talking to Mary Jane while Harry is flying around. There is a shot of the Sandman about to clap his hands together around Harry. As the scene cuts to Spiderman taking off to save Harry and cuts back, Sandman's hands are much farther apart than they were before the cut.
Continuity: During the scene on the bridge where MJ breaks up with Peter, MJ's hair is tied behind her head with a few wisps hanging down and her ears visible whenever she is shown from behind. However, whenever MJ is shown in her own close-up during the same conversation, her hair is down loosely and her ears are completely covered up.
Continuity: In the scene where Peter asks Harry to help rescue M. J. (from Venom and Sandman), a sitting chair appears to the left of the painting of Harry's father in the last shot of Harry. There was no chair in the other shots of this scene. The sitting chair was by that painting for all of the movie except those few shots.