Revealing mistake: Right after they "create" Leeloo and she is lying in the plastic cage with the little straps on her, the guy approaches her and says, "if you want out, you are going to have to work on your communication skills." She gives him a dirty look, and then you can see a huge hole, pre-cut in the glass, that she busts her hand through.
Continuity mistake: When the police confront Leeloo on the side of the building, she raises her hands and we can see that they're covered in soot. She jumps off and lands in Korben's cab. When she comes to, she presses her hand against the glass, and her hand is magically clean.
Continuity mistake: When Zorg is first seen walking, and the screen only shows his legs, there is an audible clank as he steps with his RIGHT leg. After that, the clank is heard from his left foot.
Continuity mistake: After Leeloo fights the Mangalores in the Diva's room but then has to give the stones box to Zorg, she throws it to him with forward rotation but when the box is shown flying through the air in slow motion, it's rotating backwards.
Other mistake: In the scene in the beginning when you first see the fifth element, and the camera moves up so you see the wide open mouth, look to the shoulder on the left. In the years of undisturbed dust, there are a few finger prints.
Continuity mistake: When the cops go looking for Korben and Leeloo in the fog, there are two orange light sticks hanging from the ceiling inside their car. From the outside looking in they are swinging from side to side very quickly. But from the inside looking out they are swinging from side to side very slowly.