Revealing mistake: Right after they "create" Leeloo and she is lying in the plastic cage with the little straps on her, the guy approaches her and says, "if you want out, you are going to have to work on your communication skills." She gives him a dirty look, and then you can see a huge hole, pre-cut in the glass, that she busts her hand through.
Continuity mistake: When the police confront Leeloo on the side of the building, she raises her hands and we can see that they're covered in soot. She jumps off and lands in Korben's cab. When she comes to, she presses her hand against the glass, and her hand is magically clean.
Other mistake: In the scene in the beginning when you first see the fifth element, and the camera moves up so you see the wide open mouth, look to the shoulder on the left. In the years of undisturbed dust, there are a few finger prints.
Continuity mistake: When Billy shouts at the Priest while holding the gun, there is a tripod standing behind Billy to his right. Billy yells, "Don't move." The shot changes to the Priest and then back to Billy again when Billy says, "I have a gun" you notice that the tripod behind him has disappeared. The tripod reappears in the overhead shot where the Priest says, "I'll explain everything."
Continuity mistake: When Zorg's henchman is on the phone with Zorg and Zorg blows him up. As the smoke clears and the fires die down, the body of the henchman is still standing at the phone.
Continuity mistake: When LeeLoo is on the ledge outside of the building, the police corner her & take her picture. Her face is pretty calm, but when the picture is developed on the police screen, she looks shocked.