During the scene when Dolarhyde takes Reba to the zoo, the tiger she pets is not sedated. Because of the humane society they could not sedate the tiger. Instead the trainer is to the left just out of the shot keeping the tiger calm.

Frankie Faison reprises his role as Barney from "The Silence of the Lambs" and "Hannibal." He is the only actor to appear in all four Hannibal Lecter films, having played Lt. Fisk in "Manhunter."