Plot hole: The dead young girl who wears white has hemophilia (uncontrollable bleeding), and her mother states that she's scared of all sharp metal objects (scissors, etc.), yet she goes to play in an old abandoned steel mill all the time.
Plot hole: Okay, so Jeanie (or Jeanine, I dunno) was a hemophiliac (she bleeds a LOT). Now, they said that she died by her worst fear, which was knives. The Doctor tortured her for TWO DAYS. Even if he didn't use knives the whole time, she would have been dead well before, having bled to death long before the 48 hours came to pass, because even bruises can be severely dangerous to someone with her condition.
Continuity mistake: The second time the female detective is watching the video of the German kids, the events on the tape has changed. The first time the video is shown, the German girl takes her clothes off, then it shows them at the computer. The second time she is watching it alone, the video goes from them wrestling around to the computer scene.
Continuity mistake: In the scene where Terry's boss is walking through what appears to be a train yard, he sees the little girl standing on the end of the train. Immediately after, we see him pulling a cigarette out of his mouth. The camera switches back to the train (which is now empty) before switching back to Terry's boss where we see him pull the cigarette out of his mouth a second time.
Continuity mistake: In the scene where Natasha McElhone sees her boss dead in the morgue, the first shot of her boss shows him with his mouth wide open with his tongue & teeth showing. The next shot, his teeth are no longer showing.