Other mistake: Towards the end of the film, after Snipes beats the crap out of a lot of vampires, Whistler throws Blade's sunglasses to him. They show him throw them in one shot, then in the next shot they show Snipes catching them. But look in the background at Whistler, he doesn't have the glasses, but is moving his arm like he is throwing them. The glasses must have been computer animated, and bad editing contributed to this mistake.
Revealing mistake: When Damoscinos is dying, just after being bitten, he stumbles to the ground. As he does so, you can see the tube feeding the green "blood" to his neck on the ground behind him.
Continuity mistake: After Nomak rips into Damaskinos's neck, Damaskinos backs up with no blood on his face, but in the next shot, his mouth is suddenly covered in blood and he is spitting up blood rapidly from his mouth.
Continuity mistake: In the middle of the film when the Bloodpack gear up ready to go out and into the sewers to find the reapers. Blade and Nyssa are talking at a table, Whistler shouts "hey Blade, give me a hand". In this shot we see Nyssa looking at Blade, but in the following shot she is now looking down and away from Blade.
Continuity mistake: At the end of the film when Reinhardt and Whistler are in a room together, Reinhardt turns and looks at the monitors and mouths "what the f**k?" he turns his head to the side, yet in the following shot his body is side on, and he is looking right at Whistler ready for the punch.
Continuity mistake: In the opening scene, Novak is walking down a corridor with a woman, and when she says, "Where did you get that scar on your chin? " Novak puts his hand to his mouth to cover it when he coughs, but in the shot from the security camera and normal view his hand is not at his mouth.
Revealing mistake: This is during the fight between Blade and Nomak at the House of Pain. While Blade is walking across the wooden platform, you can see Nomak readying himself to get launched on the platform.
Continuity mistake: When Blade is fighting the henchmen near the end, he lifts the last surviving one into the air and you can see Blade's hand through the henchman's throat and it is obviously a dummy. Then, when he falls backwards, his hand is not on his throat, it is on the henchman's shoulder.
Revealing mistake: When Blade slices Reinhardt in half, as the sunglasses fly off the two halves of his face you can briefly see that Reinhardt (or more precisely the CGI model of him) has no eyes.
Continuity mistake: When Blade meets the Bloodpack for the first time, Reinhardt (Ron Perlman) tries to instigate him, and the rest of the Bloodpack draw their weapons on him. When Nyssa motions for them to put their weapons away, we see a shot of the entire group putting their weapons down. Snowman(Donnie Yen) had partially drawn his sword, and resheathes it. Immediately afterwards it shows him doing this again.
Other mistake: At the end of the movie, when Novak bites Nyssa, Nyssa is screaming. You can clearly see mercury-amalgam fillings in her teeth.