The picture on the computer of the hive looks like an upside down umbrella and the name of the corporation who own the hive is ... the Umbrella corporation.

In the final scene when Milla Jovovich emerges from Racoon City Hospital into the ruined city, a newspaper blows past in the wind with the headline "The Dead Walk" – a blatant reference to George Romero’s classic zombie flick "Day of the Dead" where a newspaper with the same headline blows past in the opening sequence.

The scene where the licker crawls over the wall to Spence with its tongue flicking, is reminiscent of a scene in the game 'Resident Evil 2' where the player sees the licker for the very first time.

The group has 3 hours to make it out before the exit is sealed shut. In all of the Resident Evil games, if you beat the game in under 3 hours, you usually get really souped up weapons as a bonus.

If you're inclined to look for such things - at the end of the movie, where Milla Jovovich falls from the bed in that white room. If you see the shot in slow motion you can clearly see everything that is hidden under that white towel or whatever it is.

The train which the heroes catch to and from the umbrella facility is remarkably similar to the train you catch at the end of Resident Evil 2 to end the game.

During the 'laser fry' sequence, the team leader gets his survival knife sliced in two. I find this rather amusing since the survival knife is a weapon that has cropped up in all the Resident Evil games but is as useful to your character as a toothpick.

A subtle reference to the games: The name on the front of the transit train is 'Alexia'. This could be a reference to Alexia Ashford, an Umbrella researcher who appeared in 'Resident Evil: Code Veronica'. I'm also fairly certain the names 'Red Queen' and 'Hive' are attributed to Alexia's fanatical obsession with ants and the fact that the T-Virus, in the games, was supposedly discovered in an ant corpse.

When the zombies have just appeared and everybody is panicking, JD manages to get the door which is locked, open and a whole gang load of zombies grab him. That scene is taken from other numerous scenes of George A.Romero's masterpiece 'Day of the Dead'.

In the movie, the character Spence betrays the rest of the group. In the game, the character Lord Ozwell E. Spencer betrays the two scientists he worked with by stealing the viruses they created for his own company Umbrella.

In the final scene in which Alice is leaving the Raccoon City Hospital, a paper is shown with the title "The Dead Walk." The date is September 24, 2002 on the paper. In the game in which the movie is based on the government had nuked the city four years beforehand.

At the end, when the scientists are dragging the infected guy away, they make a reference to the 'Nemesis Project.' In Resident Evil 3, the subtitle is 'Nemesis' because a giant Tyrant called Nemesis is chasing about the player.

All the cast and crew (including the producer) had to undergo a grueling one week of military training (which they dubbed their 'week of hell') under the supervision of a battle hardened ex-navy SEAL. By the end most people were naturally eager to give their trainer a little of his own medicine. Miss Jovovich (Alice) did: he's the zombie she head kicks into the test-tube cabinet and then steals the gun from (before fighting the zombie dogs). What sweet justice.

George A. Romero was the original choice for writer and director for this project, and got as far as writing a script (which can be read on http://www.allmoviescripts.com/scripts/14934168593f510427668d1.html), but left due to creative differences.

The script went through many changes even as the crew was working on the movie. One version of the end declared a happy end - Alice and Matt 'riding off into the sunset' after having escaped the Hive; but that idea was dropped for the sake of continuity.

When Spence enters the secured room where the T-Virus was stored he suddenly experiences the flashback of him stealing it. This is remarkably similar to what happens to Ark Thompson in the game 'Resident Evil: Survivor'. He wakes up with no memory of who he is, fights his way into a lab complex and suddenly remembers everything before encountering a Virus experiment gone wrong. I don't think it was done intentionally but it's an interesting game reference nonetheless.

The voice of the narrator, as well as one of the surgeons at the end, is played by an uncredited Jason Isaacs, who appears in nearly all of director Paul Anderson's films.

Fans of the games were disappointed that no game characters appeared, however they are referenced twice at the end of the movie. The newspaper seen on the stand in the foreground as Alice leaves the hospital has a sub-headline mentioning the Special Tactics And Rescue Squad police unit, and a police car next to the one Alice gets the shotgun from has the S.T.A.R.S. emblem on the bonnet.

According to the director, "Red Queen" is a reference to Alice in Wonderland.

As an interesting homage to the movie, the latest Resident Evil game, Resident Evil 4, contains a segment in which your character must make his way down a laser swamped corridor similar to the one outside the Red Queens chamber.