Continuity: When they bring in the car crash victim (future heart donor), the victim is in perfect condition. No blood, broken bones or anything. Pretty good to have been hit by a truck.
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The message "For Sasha" which appears just before the end credits is a dedication to director Nick Cassavetes' daughter. See more...
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Factual error: There is a scene where John Q's son whispers to him with a breathing tube down his throat. It is physically impossible to speak, even whisper, with a breathing tube.
Other: At the beginning, when the woman is driving she pulls up behind a truck she wants to pass. She sticks her head out of her window to see if there is anybody coming and her hair doesn't move at all.
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