Continuity: In the scene where Frost has the head pure-blood vampire on the beach, after he pulls out his first vampire tooth you see blood all over his mouth, but when it shows the closeup of him pulling out the other tooth, there is no blood.

Continuity: When Blade gets his serum, Whistler holds his hand, then they see the girl run. In one shot, Whistler goes right, leaving the suffering Blade. In the next shot (close up on Blade), you can see that Whistler is still holding Blade's hand.

Continuity: In the big fight scene in the end between Blade and Frost, the blood smear on Frost's face changes sides a few times.

Continuity: The bloody makeup on Whistler's face and neck changes constantly throughout the scene when he gives his last words.