Plot hole: When the survivors first make an attempt to break out towards the station they kill numerous assailants at close quarters and yet only one of them (Uno) is infected. There must be dozens of the parasites floating around, enough to infect them all.

Continuity: According to Ballard at the beginning, a captain wears two bars (as per modern US insignia). However, Braddock wears two bars and her rank is given as Commander throughout the film.

Continuity: Early in the movie, when Ice Cube is accidentally released by the two rookie cops, Natasha Henstridge offers herself as a hostage to obtain the release of the blonde rookie. Ice cube switches hostages and holds a knife to Natasha's throat. Right as she slips out of his hold, the knife pushes against her neck and for a split second you see the blade bend.

Revealing: Have a look at the shot of the rear part of the train exploding as the locomotive pulls away from it. If there was ever a more obvious model shot, with cheesy, jerky bouncing toy trains and Action Man (TM) dolls, then I haven't seen it.

Continuity: When everyone is exiting the back door of the prison, the police officers and Ice Cube are fighting creatures in the ally. After Ice Cube moves out of the way, the last male police officer is fighting, and when he headbutts one of the creatures he does not make contact.

Plot hole: When Natasha Henstridge and Ice Cube try to get away from Shining Canyon before the reactor explodes some of the insane miners jump onto the train. Ice Cube says he wants to "lighten the load" and grabs some of the detonators. Henstridge replies that there is some dynamite in one of the cars. Why didn't they use it during the final fight? They only used the detonators. (Time)

Continuity: After Melanie's "plan A" failed since the train is not at the station the group fights its way back to the prison. During that fight they kill quite a lot of the possessed miners. But in one of the following scene when those freaks assemble in the streets and walk to the prison there are only four or five bodies lying around.

Continuity: In the train scene the rookie girl shoots, takes a step back and Ice Cube comes in front and throws a grenade. This happens 4 times, but in fact they just use the same footage 4 times.