Revealing: While the guys are going for their physicals, there's a scene in which blood is drawn and you can clearly see the tube connected to the end of the syringe pumping fake blood into the container.

Plot hole: When the astronauts finally get to IKON, everyone is amazed at how big it is. Now come on! Russia begs the U.S. to fix their satellite, NASA spends about a billion dollars getting a mission up there, man-years are spent training astronauts, and they don't even know what the satellite looks like?

Factual error: At the end, the russian satelite is aimed straight at the moon. It couldn't have been done that way, and if they did aim at the moon, they would have had to aim to where it would be in 3 days.

Factual error: A couple of times during the film, someone exclaims in horror that if this-or-that system fails, they will have to land the shuttle dead-stick (unpowered; no chance to veer off and try again). Actually, all shuttle landings are dead-stick; they are computer guided but nevertheless are unpowered, one-shot deals.

Continuity: During the climactic landing sequence at the end, the point of view shifts rapidly from head-on to alongside and back. Watch carefully at the first side-on view just as they're touching down; the nose of the shuttle says "Columbia". When it switches to the next head-on view, the wings say "Daedalus".

Visible crew/equipment: You can see reflections of film crew and lighting boards in Clint Eastwood's sunglasses several times during the scenes where he is gathering the old members of team Daedalus.

Continuity: This line of thinking is repeated twice, once by the NASA scientist and once by the Tommy Lee Jones character: "To get to the moon, you only have to go halfway - gravity will take you the rest of the way". Actually, since Earth's gravity is 6 times greater than the moon's, you would have to go 6/7ths of the way, otherwise you return to Earth.

Continuity: When the rockets blasted on the Russian satellite, it should have cleared all the debris surrounding it.